| First Author | Azen EA | Year | 1986 |
| Journal | Am J Hum Genet | Volume | 39 |
| Pages | A146 (Abstr.) | Mgi Jnum | J:12143 |
| Mgi Id | MGI:60393 | Citation | Azen EA, et al. (1986) Close linkage of mouse genes for salivary proline-rich proteins (PRPs) and taste. Am J Hum Genet 39:A146 (Abstr.) |
| abstractText | Full text of Abstract: A146 GENE MAPPING AND LINKAGE. (432) 20.63. CLOSE LINKAGE OF MOUSE GENES FOR SALIVARY PROLINE-RICH PROTEINS (PRPs) AND TASTE. E.A. Azen, Univ. o f Wisconsin, Madison, I.E. Lush, Univ. College, London, B.A. Taylor, The Jackson Laboratory, Bar Harbor, Maine. PRPs constitute two-thirds of proteins secreted by human parotid glands. Thirteen different protein polymorphisms have been described among PRPs and the six genes coding for these polymorphisms are closely linked on chromosome 12p13.2. In the mouse, as in the human, PRPs are determined by a multigene family that has been assigned to chromosome 8. The functions of the many human PRPs are largely unknown, however, it is possible, from this work in mice, that PRPs may be involved in tasting. Inbred strains of mice differ greatly in their ability to taste certain bitter substances, and genes for taste have been identified using RI strains, particularly the BXD and CXB sets. DNAs of the same RI strains differ with respect to several Hind III restriction endonuclease sites within or near the mouse PRP genes. These strain differences in restriction patterns are detectable after Southern blotting and probing with a cDNA probe for a rat PRP. (This probe was provided D.M. Carlson, U. Calif., Davis). The BXD strain distribution pattern for Qui (quinine) was exactly the same as that for PRP genes in all twenty RI strains tested, and also for seven CXB RI strains. Thus, Qui [and two other closely linked mouse tasting genes Rua (raffinose acetate) and Cyx (cycloheximide)] are closely linked to genes for salivary PRPs (95% confidence limit for Qui-PRP gene distance=0.0 to 3.95 cM) or are even the same genes. Since homologous linkage groups may occur in man, we are currently studying families for genetic linkage between PRP salivary and PTC taste genes. |
