| Primary Identifier | MGI:3621027 | Allele Type | Targeted |
| Attribute String | Modified regulatory region, Null/knockout | Gene | Rr320 |
| Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting vector was designed to remove 5'HS1 encoded by nucleotides -4675 to -6999 relative to the Ey cap site. The removed sequence includes the core binding site, the region to which the HS maps and all regions of homology with human 5'HS1. A loxP site flanked neomycin resistance gene cassette was included in the vector. The presence of the marker had a substantial effect on expression of beta-like globin genes at all stages. |
