| Primary Identifier | MGI:3620129 | Allele Type | Transgenic |
| Attribute String | Reporter | Gene | Tg(Cp-EGFP)25Gaia |
| Strain of Origin | (C57BL/6J x SJL/J)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | EGFP is expressed from this transgene when the promoter is activated by binding to the upstream CBF1 binding elements of a complex comprising CBF1, the transcriptional coactivator mastermind like 1 (Drosophila)(MML1), and the intracellular cleavage product resulting from interaction of the transmembrane Notch receptor with ligand. |
| molecularNote | The transgene comprises four tandem copies of the C-promoter binding factor 1 (CBF1/RBPSUH) binding site of the Epstein-Barr virus major latency C promoter (Cp), followed by the SV40 minimal promoter and the coding sequence for enhanced green fluorescent protein. Cells of mice bearing this transgene express green fluorescent protein when the Notch signaling pathway is activated. |
