| First Author | Kawashima T | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 6 | Pages | 1187-97 |
| PubMed ID | 23791646 | Mgi Jnum | J:207579 |
| Mgi Id | MGI:5559136 | Doi | 10.1016/j.immuni.2013.02.024 |
| Citation | Kawashima T, et al. (2013) Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-beta. Immunity 38(6):1187-97 |
| abstractText | The small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered interferon-beta (IFN-beta) production, which protected mice from experimental colitis. The LAB-induced IFN-beta response was diminished by dsRNA digestion and treatment with endosomal inhibitors. Pathogenic bacteria contained less dsRNA and induced much less IFN-beta than LAB, and dsRNA was not involved in pathogen-induced IFN-beta induction. These results identify TLR3 as a sensor to small intestinal commensal bacteria and suggest that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses. |
