Primary Identifier | MGI:3623417 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Crlf2 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting construct was designed to delete all exons of the locus and replace them with a neomycin resistance gene. The inactivation of the gene was confirmed by the defective response of mutant splenocytes compared with wild-type to treatment with anti-CD3 plus TSLP versus anti-CD3 alone. |