| First Author | Li GC | Year | 1998 |
| Journal | Mol Cell | Volume | 2 |
| Issue | 1 | Pages | 1-8 |
| PubMed ID | 9702186 | Mgi Jnum | J:48929 |
| Mgi Id | MGI:1276221 | Doi | 10.1016/s1097-2765(00)80108-2 |
| Citation | Li GC, et al. (1998) Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. Mol Cell 2(1):1-8 |
| abstractText | We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70(-/-) mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70(-/-) mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4(+)CD8(+) tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression. |
