| First Author | Iwase S | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 13 | Pages | 3129-35 |
| PubMed ID | 16684532 | Mgi Jnum | J:109077 |
| Mgi Id | MGI:3625674 | Doi | 10.1016/j.febslet.2006.04.065 |
| Citation | Iwase S, et al. (2006) A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice. FEBS Lett 580(13):3129-35 |
| abstractText | BHC80 is a component of BRAF-HDAC complex (BHC) involved in transcriptional repression of neuron-specific genes in non-neuronal cells. However, BHC80 is present in both neuronal and non-neuronal cells. To explore the physiological importance of BHC80 in vivo, and the precise mechanism underlying neuron-specific gene repression by BHC80, we have produced mutant mice lacking Bhc80. The loss of Bhc80 resulted in neonatal lethality without sucking mother's breast milk sufficiently. Although Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, Bhc80 is indispensable for the survival of neonatal pups. |
