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Publication : Altered nociceptive response in ADAM11-deficient mice.

First Author  Takahashi E Year  2006
Journal  Brain Res Volume  1097
Issue  1 Pages  39-42
PubMed ID  16729981 Mgi Jnum  J:110471
Mgi Id  MGI:3640265 Doi  10.1016/j.brainres.2006.04.043
Citation  Takahashi E, et al. (2006) Altered nociceptive response in ADAM11-deficient mice. Brain Res 1097(1):39-42
abstractText  Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
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