| Primary Identifier | MGI:3626317 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Mt1-Tnfsf4)1Pgn |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| description | This line is representative of four transgenic lines. According to the authors, although the line 2 was the primary one described in the reference, all four share the same phenotype. |
| molecularNote | The Tnfsf4 cDNA, amplified from mRNA isolated from spleens of C57BL/6J mice, was placed under control of the ubiquitously expressed metallothionein promoter followed by the hemoglobin beta IVS intron. The 3' end of the cDNA, without its polyadenylation signal, was joined to a fragment of the human growth hormone gene, which distinguishes transgene-derived from endogenous transcripts. Transgenic mice express 4- to 250-fold higher levels, depending on tissue type, of transgenic mRNA than do nontransgenic littermates in liver, aorta, heart and spleen. |
