| First Author | Escudero B | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 4 | Pages | e93074 |
| PubMed ID | 24691161 | Mgi Jnum | J:215044 |
| Mgi Id | MGI:5604574 | Doi | 10.1371/journal.pone.0093074 |
| Citation | Escudero B, et al. (2014) Polmu deficiency increases resistance to oxidative damage and delays liver aging. PLoS One 9(4):e93074 |
| abstractText | Polmu is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polmu (Polmu(-/-)) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polmu(-/-) mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polmu(-/-) deficiency on liver aging. We found that old Polmu(-/-) mice (>20 month) have greater liver regenerative capacity compared with wt animals. Old Polmu(-/-) liver showed reduced genomic instability and increased apoptosis resistance. However, Polmu(-/-) mice did not show an extended life span and other organs (e.g., heart) aged normally. Our results suggest that Polmu deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. |
