| First Author | Kuo CT | Year | 1997 |
| Journal | Science | Volume | 277 |
| Issue | 5334 | Pages | 1986-90 |
| PubMed ID | 9302292 | Mgi Jnum | J:43131 |
| Mgi Id | MGI:1097188 | Doi | 10.1126/science.277.5334.1986 |
| Citation | Kuo CT, et al. (1997) LKLF: A transcriptional regulator of single-positive T cell quiescence and survival [see comments]. Science 277(5334):1986-90 |
| abstractText | Mature single-positive (SP) T lymphocytes enter a resting state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand-induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood. |
