Primary Identifier | MGI:3640128 | Allele Type | Targeted |
Gene | Del(16Cldn5-Hira)5Bld | Transmission | Germline |
Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | In an ES cell line in which a loxP site previously had been inserted into the Hira gene by homologous recombination, a second loxP site was inserted into the genome between the Gp1bb and Cldn5 genes using a retrovirus. Transient cre-expression in the ES cells resulted in deletion of a 150-kb region from Cldn5 to Hira. |