| First Author | Liu P | Year | 1998 |
| Journal | Genetics | Volume | 150 |
| Issue | 3 | Pages | 1155-68 |
| PubMed ID | 9799267 | Mgi Jnum | J:50799 |
| Mgi Id | MGI:1309737 | Doi | 10.1093/genetics/150.3.1155 |
| Citation | Liu P, et al. (1998) Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics 150(3):1155-68 |
| abstractText | Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality. |
