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Publication : Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.

First Author  Oulé M Year  2021
Journal  iScience Volume  24
Issue  8 Pages  102876
PubMed ID  34386734 Mgi Jnum  J:311870
Mgi Id  MGI:6780796 Doi  10.1016/j.isci.2021.102876
Citation  Oule M, et al. (2021) Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. iScience 24(8):102876
abstractText  The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.
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