| First Author | Darakhshan F | Year | 2006 |
| Journal | Carcinogenesis | Volume | 27 |
| Issue | 2 | Pages | 311-8 |
| PubMed ID | 16093251 | Mgi Jnum | J:105074 |
| Mgi Id | MGI:3613399 | Doi | 10.1093/carcin/bgi207 |
| Citation | Darakhshan F, et al. (2006) Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis 27(2):311-8 |
| abstractText | The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk. |
