| First Author | Madsen DH | Year | 2014 |
| Journal | Biochem J | Volume | 461 |
| Issue | 3 | Pages | 487-95 |
| PubMed ID | 24832573 | Mgi Jnum | J:215250 |
| Mgi Id | MGI:5604957 | Doi | 10.1042/BJ20140337 |
| Citation | Madsen DH, et al. (2014) TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Biochem J 461(3):487-95 |
| abstractText | Membrane-anchored serine proteases serve as important regulators of multiple developmental and homoeostatic processes in mammals. TMPRSS13 (transmembrane protease, serine 13; also known as mosaic serine protease large-form, MSPL) is a membrane-anchored serine protease with unknown biological functions. In the present study, we used mice with the Tmprss13 gene disrupted by a beta-galactosidase-neomycin fusion gene insertion to study the expression and function of the membrane-anchored serine protease. High levels of Tmprss13 expression were found in the epithelia of the oral cavity, upper digestive tract and skin. Compatible with this expression pattern, Tmprss13-deficient mice displayed abnormal skin development, leading to a compromised barrier function, as measured by the transepidermal fluid loss rate of newborn mice. The present study provides the first biological function for the transmembrane serine protease TMPRSS13. |
