| First Author | Zhang M | Year | 2011 |
| Journal | Cell Mol Immunol | Volume | 8 |
| Issue | 6 | Pages | 502-4 |
| PubMed ID | 21946435 | Mgi Jnum | J:335028 |
| Mgi Id | MGI:6806185 | Doi | 10.1038/cmi.2011.42 |
| Citation | Zhang M, et al. (2011) Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol 8(6):502-4 |
| abstractText | An antiviral innate immune response involves induction of type I interferons (IFNs) and their subsequent autocrine and paracrine actions, but the underlying regulatory mechanisms are incompletely understood. Here we report that CYLD, a deubiquitinase that specifically digests lysine 63-linked ubiquitin chains, is required for antiviral host defense. Loss of CYLD renders mice considerably more susceptible to infection by vesicular stomatitis virus (VSV). Consistently, CYLD-deficient dendritic cells are more sensitive to VSV infection. This functional defect was not due to lack of type I IFN production but rather because of attenuated IFN receptor signaling. In the absence of CYLD, IFN-beta is ineffective in the induction of antiviral genes and protection of cells from viral infection. These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling. |
