| First Author | Thiel AT | Year | 2010 |
| Journal | Cancer Cell | Volume | 17 |
| Issue | 2 | Pages | 148-59 |
| PubMed ID | 20159607 | Mgi Jnum | J:157685 |
| Mgi Id | MGI:4436779 | Doi | 10.1016/j.ccr.2009.12.034 |
| Citation | Thiel AT, et al. (2010) MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell 17(2):148-59 |
| abstractText | Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MLL fusion proteins (MLL-FPs). Here, we show that menin recruits both wild-type MLL and oncogenic MLL-AF9 fusion protein to the loci of HOX genes to activate their transcription. Wild-type MLL not only catalyzes histone methylation at key target genes but also controls distinct MLL-AF9-induced histone methylation. Notably, the wild-type Mll allele is required for MLL-AF9-induced leukemogenesis and maintenance of MLL-AF9-transformed cells. These findings suggest an essential cooperation between an oncogene and its wild-type counterpart in MLL-AF9-induced leukemogenesis. |
