| Primary Identifier | MGI:3664559 | Allele Type | Targeted |
| Attribute String | Modified isoform(s) | Gene | Kitl |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 6 was replaced with a neomycin selection cassette. This alternatively spliced exon 6 encodes the major proteolytic cleavage site for the generation of the soluble encoded protein. Homozygous mice express only a transcript that encodes the transmembrane bound form. However, reduced levels of a soluble form of the encoded protein is found in serum of homozygous mice, suggesting that a secondary proteolytic cleavage site is used. |
