| First Author | Smith AD | Year | 2019 |
| Journal | PLoS One | Volume | 14 |
| Issue | 9 | Pages | e0223025 |
| PubMed ID | 31560732 | Mgi Jnum | J:280038 |
| Mgi Id | MGI:6364058 | Doi | 10.1371/journal.pone.0223025 |
| Citation | Smith AD, et al. (2019) Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection. PLoS One 14(9):e0223025 |
| abstractText | Clostridium difficile (Cd) infection (CDI) typically occurs after antibiotic usage perturbs the gut microbiota. Mucosa-associated invariant T cells (MAIT) are found in the gut and their development is dependent on Major histocompatibility complex-related protein 1 (MR1) and the host microbiome. Here we were interested in determining whether the absence of MR1 impacts resistance to CDI. To this end, wild-type (WT) and MR1-/- mice were treated with antibiotics and then infected with Cd spores. Surprisingly, MR1-/- mice exhibited resistance to Cd colonization. 16S rRNA gene sequencing of feces revealed inherent differences in microbial composition. This colonization resistance was transferred from MR1-/- to WT mice via fecal microbiota transplantation, suggesting that MR1-dependent factors influence the microbiota, leading to CDI susceptibility. |
