| First Author | Trivedi S | Year | 2020 |
| Journal | Elife | Volume | 9 |
| PubMed ID | 33164745 | Mgi Jnum | J:298678 |
| Mgi Id | MGI:6477099 | Doi | 10.7554/eLife.55615 |
| Citation | Trivedi S, et al. (2020) Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. Elife 9:e55615 |
| abstractText | Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands. We investigated MAIT cells during clinical and experimental sepsis, and their contribution to host responses. In experimental sepsis, MAIT-deficient mice had significantly increased mortality and bacterial load, and reduced tissue-specific cytokine responses. MAIT cells of WT mice expressed lower levels of IFN-gamma and IL-17a during sepsis compared to sham surgery, changes not seen in non-MAIT T cells. MAIT cells of patients at sepsis presentation were significantly reduced in frequency compared to healthy donors, and were more activated, with decreased IFN-gamma production, compared to both healthy donors and paired 90-day samples. Our data suggest that MAIT cells are highly activated and become dysfunctional during clinical sepsis, and contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis. |
