| First Author | Lindner C | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 8 | Pages | 880-8 |
| PubMed ID | 26147688 | Mgi Jnum | J:257907 |
| Mgi Id | MGI:6120618 | Doi | 10.1038/ni.3213 |
| Citation | Lindner C, et al. (2015) Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat Immunol 16(8):880-8 |
| abstractText | Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn. |
