| First Author | Sugimoto M | Year | 2007 |
| Journal | PLoS Genet | Volume | 3 |
| Issue | 7 | Pages | e116 |
| PubMed ID | 17676999 | Mgi Jnum | J:123745 |
| Mgi Id | MGI:3719493 | Doi | 10.1371/journal.pgen.0030116 |
| Citation | Sugimoto M, et al. (2007) X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet 3(7):e116 |
| abstractText | During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps. |
