| First Author | Tu J | Year | 2018 |
| Journal | Exp Cell Res | Volume | 373 |
| Issue | 1-2 | Pages | 71-79 |
| PubMed ID | 30266657 | Mgi Jnum | J:269967 |
| Mgi Id | MGI:6271732 | Doi | 10.1016/j.yexcr.2018.09.018 |
| Citation | Tu J, et al. (2018) MicroRNA-26b promotes transition from Kit(-) to Kit(+) mouse spermatogonia. Exp Cell Res 373(1-2):71-79 |
| abstractText | During spermatogenesis, a group of undifferentiated spermatogonia undergoes an essential transition to a differentiating stage, which involves gain of Kit receptor. In the current study, we showed that a small non-coding RNA, miRNA-26b could induce transition from Kit(-) to Kit(+) and inhibit proliferation of spermatogonia. A key transcriptional factor for undifferentiated spermatogonia, Plzf, was proven as a direct target of miR-26b. When undifferentiated spermatogonia were treated with Retinoic acid (RA), miR-26b was increased, further promoting RA-induced differentiation of spermatogonia. In addition, miR-26b could repress 5-hydroxymethylcytosine (5hmC) via repression of Tet3 in spermatogonia. These findings demonstrate that miR-26b might play a role in promoting the transition from Kit(-) to Kit(+) SSCs. |
