| First Author | Boughter JD Jr | Year | 1995 |
| Journal | Behav Genet | Volume | 25 |
| Issue | 3 | Pages | 233-7 |
| PubMed ID | 7598666 | Mgi Jnum | J:25226 |
| Mgi Id | MGI:72953 | Doi | 10.1007/BF02197181 |
| Citation | Boughter JD Jr, et al. (1995) C3.SW-Soaa heterozygous congenic taster mice. Behav Genet 25(3):233-7 |
| abstractText | Sensitivity to the bitter acetylated sugar sucrose octaacetate (SOA) is mediated by a single-locus system with three alleles in mice. Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity). A congenic quartet created from taster and nontaster strains has been used to investigate the effect of the Soa locus on non-SOA aspects of taste sensitivity. In this study, we created a third congenic set, C3.SW-Soaa, from taster (SWR/J) and demitaster (C3HeB/FeJ) strains. After 11 lineal backcross generations these C3.SW mice carry the tasting allele on a 99% C3 demitaster background. After testing a total of 938 mice, taster-demitaster proportions across 12 generations were consistent with expectations from a monogenic model. The resultant three-strain congenic series will allow further examination of the mechanisms of taste. |
