| First Author | Kudek MR | Year | 2023 |
| Journal | J Immunol | Volume | 210 |
| Issue | 9 | Pages | 1281-1291 |
| PubMed ID | 36920384 | Mgi Jnum | J:353666 |
| Mgi Id | MGI:7471363 | Doi | 10.4049/jimmunol.2101011 |
| Citation | Kudek MR, et al. (2023) Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase alpha-Deficient Mice. J Immunol 210(9):1281-1291 |
| abstractText | Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGKalpha is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGKalpha, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells. |
