| Primary Identifier | MGI:3687336 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(KRT14-HGF)43Takk |
| Strain of Origin | (C57BL/6 x DBA/2)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Three stably-expressing transgenic lines were derived and designated by the authors HGFTg1, HGFTg43 and HGFTg75. Skin pigmentation of line 1 is light, of line 43 moderate and of line 75 dark. Most analyses were performed on HGTf43. |
| molecularNote | A full-length cDNA encoding human hepatocyte growth factor was inserted into an epidermis-directed expression cassette containing 2500 bp of 5' flanking plus untranslated-region DNA from the human keratin 14 gene, a rabbit beta-globin intron, and approximately 7 kb of 3' untranslated-region plus flanking sequence from the human keratin gene. Immunohistologic analysis demonstrates expression in the epidermis. |
