| First Author | Kobayashi M | Year | 2008 |
| Journal | Proc Natl Acad Sci U S A | Volume | 105 |
| Issue | 29 | Pages | 10090-4 |
| PubMed ID | 18626021 | Mgi Jnum | J:138336 |
| Mgi Id | MGI:3804799 | Doi | 10.1073/pnas.0801648105 |
| Citation | Kobayashi M, et al. (2008) Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A 105(29):10090-4 |
| abstractText | A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9-23 peptide sequence in type 1 diabetes. Anti-insulin B:9-23 T cell clones isolated from prediabetic NOD islets have a conserved Valpha-segment/Jalpha-segment, but no conservation of the alpha-chain N region and no conservation of the Vbeta-chain. Here, we show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transgenically or retrogenically introduced into mice without its corresponding Vbeta. We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor. |
