| First Author | Hahn WO | Year | 2020 |
| Journal | Virulence | Volume | 11 |
| Issue | 1 | Pages | 594-606 |
| PubMed ID | 32407154 | Mgi Jnum | J:306692 |
| Mgi Id | MGI:6706210 | Doi | 10.1080/21505594.2020.1768329 |
| Citation | Hahn WO, et al. (2020) B cell intrinsic expression of IFNlambda receptor suppresses the acute humoral immune response to experimental blood-stage malaria. Virulence 11(1):594-606 |
| abstractText | Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNlambda), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNlambda signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNlambda-signaling in the initiation of the humoral immune response in the host response to experimental malaria. |
