| First Author | Hoogeboom R | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 8 | Pages | 2342-2353 |
| PubMed ID | 29791846 | Mgi Jnum | J:270850 |
| Mgi Id | MGI:6278789 | Doi | 10.1016/j.celrep.2018.04.087 |
| Citation | Hoogeboom R, et al. (2018) Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation. Cell Rep 23(8):2342-2353 |
| abstractText | B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa. Here, we show that B cell-specific deletion of the myosin IIa heavy chain reduced the numbers of bone marrow B cell precursors and splenic marginal zone, peritoneal B1b, and germinal center B cells. In addition, myosin IIa-deficient follicular B cells acquired an activated phenotype and were less efficient in chemokinesis and extraction of membrane-presented antigens. Moreover, myosin IIa was indispensable for cytokinesis. Consequently, mice with myosin IIa-deficient B cells harbored reduced serum immunoglobulin levels and did not mount robust antibody responses when immunized. Altogether, these data indicate that myosin IIa is a negative regulator of B cell activation but a positive regulator of antigen acquisition from antigen-presenting cells and that myosin IIa is essential for B cell development, proliferation, and antibody responses. |
