| Primary Identifier | MGI:3690457 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO-EGFR*delta19)11Hev |
| Strain of Origin | (C57BL/6 x CBA)F2 | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| description | Line 9 was also generated. |
| molecularNote | A mutant human epidermal growth factor receptor cDNA lacking the segment encoded by exon 19 was cloned between the tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under the control of a tissue-specific promoter can be induced to express the mutant EGFR in tissues or cell types of interest by administration/withdrawal of doxycycline. |
