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Allele : Tg(Myh6-Mmp2*V107G)712Ajb transgene insertion 712, Anthony J Baker
Primary Identifier  MGI:3689961 Allele Type  Transgenic
Attribute String  Constitutively active, Inserted expressed sequence Gene  Tg(Myh6-Mmp2*V107G)712Ajb
Strain of Origin  (129/Sv x CD-1)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene consists of a constitutively active rat Mmp2, with valine 107 in the prodomain mutagenized to glycine which results in the unfolding of the prodomain from the catalytic site, under the control of the cardiac specific alpha-myosin heavy chain promoter. In situ zymography confirmed that hearts exhibit increased Mmp2 activity.
  • mutations:
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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