| First Author | Jain V | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 8 | Pages | 110410 |
| PubMed ID | 35196487 | Mgi Jnum | J:321720 |
| Mgi Id | MGI:6881882 | Doi | 10.1016/j.celrep.2022.110410 |
| Citation | Jain V, et al. (2022) Gain control by sparse, ultra-slow glycinergic synapses. Cell Rep 38(8):110410 |
| abstractText | In the retina, ON starburst amacrine cells (SACs) play a crucial role in the direction-selective circuit, but the sources of inhibition that shape their response properties remain unclear. Previous studies demonstrate that approximately 95% of their inhibitory synapses are GABAergic, yet we find that the light-evoked inhibitory currents measured in SACs are predominantly glycinergic. Glycinergic inhibition is extremely slow, relying on non-canonical glycine receptors containing alpha4 subunits, and is driven by both the ON and OFF retinal pathways. These attributes enable glycine inputs to summate and effectively control the output gain of SACs, expanding the range over which they compute direction. Serial electron microscopic reconstructions reveal three specific types of ON and OFF narrow-field amacrine cells as the presumptive sources of glycinergic inhibition. Together, these results establish an unexpected role for specific glycinergic amacrine cells in the retinal computation of stimulus direction by SACs. |
