| First Author | Soden ME | Year | 2016 |
| Journal | Cell Rep | Volume | 16 |
| Issue | 2 | Pages | 304-13 |
| PubMed ID | 27346361 | Mgi Jnum | J:238595 |
| Mgi Id | MGI:5823129 | Doi | 10.1016/j.celrep.2016.05.067 |
| Citation | Soden ME, et al. (2016) Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior. Cell Rep 16(2):304-13 |
| abstractText | Nearly all animals engage in a complex assortment of social behaviors that are essential for the survival of the species. In mammals, these behaviors are regulated by sub-nuclei within the hypothalamus, but the specific cell types within these nuclei responsible for coordinating behavior in distinct contexts are only beginning to be resolved. Here, we identify a population of neurons in the ventral premammillary nucleus of the hypothalamus (PMV) that are strongly activated in male intruder mice in response to a larger resident male but that are not responsive to females. Using a combination of molecular and genetic approaches, we demonstrate that these PMV neurons regulate intruder-specific male social behavior and social novelty recognition in a manner dependent on synaptic release of the excitatory neurotransmitter glutamate. These data provide direct evidence for a unique population of neurons that regulate social behaviors in specific contexts. |
