Primary Identifier | MGI:3690014 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Myh6-TNNI3*G203S)4Chs |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This transgene consists of human TNNI3, with an amino acid substitution of a glycine by serine at codon 203 that causes familial hypertrophic cardiomyopathy in humans, under the control of the cardiac specific alpha-myosin heavy chain promoter. This line expresses the lowest amount of mutant protein and represents relative proportions of mutant protein of 48%. |