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Transgene : Tg(APPSwLon)96Btla transgene insertion 96, Bruce Lamb
Primary Identifier  MGI:3693358 Organism  mouse, laboratory
Chromosome  UN Mgi Type  transgene
description  PHENOTYPE: Mice hemizygous for this transgene are viable and fertile. Mutant human APP transcripts and protiens are expressed similarly to the endogenous mouse products in the brain and peripheral tissues. Amyloid beta deposits accumulate in brains. Mice are a model of familial Alzheimer's disease (FAD). [provided by MGI curators]
  • synonyms:
  • APP<K670N/M671L> and APP<V717Im>,
  • J1.96,
  • Tg(APPSwLon)96Btla,
  • transgene insertion 96, Bruce Lamb,
  • K670N/M671L + V717I
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