| First Author | Svensson M | Year | 2021 |
| Journal | Sci Rep | Volume | 11 |
| Issue | 1 | Pages | 4910 |
| PubMed ID | 33649346 | Mgi Jnum | J:305219 |
| Mgi Id | MGI:6695436 | Doi | 10.1038/s41598-021-83998-0 |
| Citation | Svensson M, et al. (2021) The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer's disease. Sci Rep 11(1):4910 |
| abstractText | Microglial cells are affected in Alzheimer's disease (AD) and interact with amyloid-beta (Abeta) plaques. Apart from memory loss, depression is common in patients with AD. Electroconvulsive therapy (ECT) is an anti-depressive treatment that may stimulate microglia, induce neuroinflammation and alter the levels of soluble Abeta, but the effects of ECT on microglia and Abeta aggregation in AD are not known. We investigated the short- and long-term effects of ECT on neuroinflammation and Abeta accumulation. 5xFAD mice received either electroconvulsive stimulation (ECS n = 26) or sham treatment (n = 25) for 3 weeks. Microglia and Abeta were analyzed in samples collected 24 h, 5 weeks, or 9 weeks after the last treatment. Abeta plaques and microglia were quantified using immunohistochemistry. The concentration of soluble Abeta and cytokines was quantified using ELISA and levels of Abeta aggregates were measured with Western Blot. Microglial phagocytosis of Abeta in the hippocampus was evaluated by flow cytometry in Methoxy-X04 injected mice 24 h following the last ECS treatment. Y-maze and Elevated plus maze were performed to study behavior after 5 weeks. We could not detect any significant short- or long-term effects of ECS on Abeta pathology or neuroinflammation, but ECS reduced abnormal behavior in the Elevated Plus maze. |
