| First Author | Majumdar S | Year | 2021 |
| Journal | Magn Reson Med | Volume | 86 |
| Issue | 1 | Pages | 405-414 |
| PubMed ID | 33604900 | Mgi Jnum | J:353809 |
| Mgi Id | MGI:7716756 | Doi | 10.1002/mrm.28709 |
| Citation | Majumdar S, et al. (2021) Longitudinal study of sub-regional cerebral viscoelastic properties of 5XFAD Alzheimer's disease mice using multifrequency MR elastography. Magn Reson Med 86(1):405-414 |
| abstractText | PURPOSE: To study sub-regional, longitudinal changes occurring inside brains of 5XFAD mice, an Alzheimer's disease (AD) model, based on viscoelastic parameters derived using MR elastography and their spatial variation. METHODS: Female 5XFAD and non-transgenic B6SJLF1/J mice as controls (n = 9 for both groups) were used for the study. Scans were performed inside a 9.4T preclinical MRI scanner using SampLe Interval Modulation-magnetic resonance elastography (SLIM-MRE). Experiments were performed at ages 2, 4, and 6 mo, and by using three actuation frequencies: 900, 1000, and 1100 Hz. Multifrequency dual elasto-visco (MDEV) reconstruction was used to combine 3D multifrequency MRE data and calculate magnitude (G *) , and phase angle phi, of the complex shear modulus G * . Mean values were measured for the overall brain and sub-regions associated with the early onset of AD, to check for the effect of aging and mouse model. Spatial coefficient of variation (CV) of both parameters across different age-groups were analyzed. RESULTS: (G *) and phi values reduced with age for overall brain in 5XFAD mice with significant difference in mean (G *) between 5XFAD and control mice at 6 mo (P = .029). Analyzing values from the hippocampal region highlighted drop in mean (G *) and phi values. The CV of (G *) inside hippocampus enabled differentiation at 4 mo with it being significantly lower in 5XFAD mice (P = .0007). CONCLUSION: Multifrequency 3D MRE revealed longitudinal viscoelastic changes in 5XFAD mice and the CV of (G *) in brain sub-regions may qualify as biomarker for early diagnosis of AD. |
