| First Author | Manji Z | Year | 2019 |
| Journal | J Alzheimers Dis | Volume | 70 |
| Issue | 4 | Pages | 1259-1274 |
| PubMed ID | 31322556 | Mgi Jnum | J:358769 |
| Mgi Id | MGI:7782780 | Doi | 10.3233/JAD-180678 |
| Citation | Manji Z, et al. (2019) 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease. J Alzheimers Dis 70(4):1259-1274 |
| abstractText | Alzheimer's disease (AD) pathology consists of extracellular deposits of amyloid-beta peptides (Abeta) and intracellular neurofibrillary tangles. These pathological alterations are accompanied by a neuroinflammatory response consisting of increased expression of inflammatory mediators. An anti-inflammatory strategy designed to prevent or delay the development of AD would benefit from knowing when neuroinflammation appears in the transgenic models during prodromal disease stages relative to Abeta pathology. We investigated the expression patterns of inflammatory mediators in the brain of 5xFAD mice in comparison to development of Abeta deposition. Expression changes in inflammatory mediators and glial markers are more robust in female mice starting at three months of age, in contrast to males in which there is no clear trend through five months. Female and male 5xFAD mice also displayed an age-dependent increase in cortical Abeta deposition congruent with neuroinflammation. Thus, in the 5xFAD mouse model of AD, administration of an anti-inflammatory agent would be most efficacious when administered before three months of age. |
