| First Author | Matharu B | Year | 2015 |
| Journal | Neuropeptides | Volume | 53 |
| Pages | 63-70 | PubMed ID | 26234669 |
| Mgi Jnum | J:351761 | Mgi Id | MGI:7664214 |
| Doi | 10.1016/j.npep.2015.07.001 | Citation | Matharu B, et al. (2015) Gadolinium-complexed Abeta-binding contrast agents for MRI diagnosis of Alzheimer's Disease. Neuropeptides 53:63-70 |
| abstractText | MRI contrast agents, containing peptide sequences that bind beta-amyloid and gadolinium ions ligated to DOTA have been synthesized for evaluation in early diagnosis of Alzheimer's Disease in transgenic mice models. A number of brain penetration modifications were incorporated and sufficient amounts of contrast agent in the brain were achieved only by addition of a cationic cell penetration sequence along with the use of microparticle assisted ultrasound activation. In the T1 mode of a MRI scan, the peptide (R2) illuminated areas of brain rich in amyloid plaques. |
