| First Author | Zhang L | Year | 2022 |
| Journal | Proc Natl Acad Sci U S A | Volume | 119 |
| Issue | 11 | Pages | e2107337119 |
| PubMed ID | 35254897 | Mgi Jnum | J:327767 |
| Mgi Id | MGI:7257725 | Doi | 10.1073/pnas.2107337119 |
| Citation | Zhang L, et al. (2022) Goal discrimination in hippocampal nonplace cells when place information is ambiguous. Proc Natl Acad Sci U S A 119(11):e2107337119 |
| abstractText | SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD. |
