| First Author | Park SW | Year | 2014 |
| Journal | Neurobiol Aging | Volume | 35 |
| Issue | 9 | Pages | 2013-20 |
| PubMed ID | 24709310 | Mgi Jnum | J:214858 |
| Mgi Id | MGI:5604084 | Doi | 10.1016/j.neurobiolaging.2014.03.008 |
| Citation | Park SW, et al. (2014) Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice. Neurobiol Aging 35(9):2013-20 |
| abstractText | Extracellular deposit of amyloid beta (Abeta) is a common pathologic feature in both age-related macular degeneration (AMD) and Alzheimer's disease, but the role of intracellular Abeta on the tight junction of the retinal pigment epithelium (RPE) is unknown. In this study, we investigated the intracellular Abeta expression and its role on the outer blood retinal barrier in the retina of 5XFAD mice, a mouse model of Alzheimer's disease. The retina of 5XFAD mice showed the pathologic features of AMD with intracellular Abeta in the RPE. As intracellular Abeta accumulated, zonular occludens-1 and occludin were markedly attenuated and lost their integrity as tight junctions in the RPE of 5XFAD mice. Also, Abeta42 uptake by ARPE-19 cells induced the tight junction breakdown of zonular occludens-1 and occludin without cell death. These results implicate that intracellular Abeta42 could play a role in the breakdown of the outer blood retinal barrier in 5XFAD mice. Thus, we suggested that 5XFAD mice could be a mouse model of dry AMD with regard to the Abeta42 related pathology. |
