| First Author | Lee Y | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 16144 |
| PubMed ID | 32999351 | Mgi Jnum | J:296342 |
| Mgi Id | MGI:6467022 | Doi | 10.1038/s41598-020-73151-8 |
| Citation | Lee Y, et al. (2020) Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model. Sci Rep 10(1):16144 |
| abstractText | Drainage of parenchymal waste through the lymphatic system maintains brain homeostasis. Age-related changes of glymphatic-lymphatic clearance lead to the accumulation beta-amyloid (Abeta) in dementia models. In this study, focused ultrasound treatment in combination with microbubbles (FUS-MB) improved Abeta drainage in early dementia model mice, 5XFAD. FUS-MB enhanced solute Abeta clearance from brain, but not plaques, to cerebrospinal fluid (CSF) space and then deep cervical lymph node (dCLN). dCLN ligation exaggerated memory impairment and progress of plaque formation and also the beneficial effects of FUS-MB upon Abeta removal through CSF-lymphatic routes. In this ligation model, FUS-MB improved memory despite accumulation of Abeta in CSF. In conclusion, FUS-MB enhances glymphatic-lymphatic clearance of Abeta mainly by increasing brain-to-CSF Abeta drainage. We suggest that FUS-MB can delay dementia progress in early period and benefits of FUS-MB depend on the effect of Abeta disposal through CSF-lymphatics. |
