| First Author | Cho WH | Year | 2014 |
| Journal | Behav Brain Res | Volume | 273 |
| Pages | 116-22 | PubMed ID | 25078295 |
| Mgi Jnum | J:217100 | Mgi Id | MGI:5613064 |
| Doi | 10.1016/j.bbr.2014.07.033 | Citation | Cho WH, et al. (2014) Learning strategy preference of 5XFAD transgenic mice depends on the sequence of place/spatial and cued training in the water maze task. Behav Brain Res 273:116-22 |
| abstractText | Learning strategy preference was assessed in 5XFAD mice, which carry 5 familial Alzheimer's disease (AD) mutations. Mice were sequentially trained in cued and place/spatial versions of the water maze task. After training, a strategy preference test was conducted in which mice were required to choose between the spatial location where the platform had previously been during the place/spatial training, and a visible platform in a new location. 5XFAD and non-transgenic control mice showed equivalent escape performance in both training tasks. However, in the strategy preference test, 5XFAD mice preferred a cued strategy relative to control mice. When the training sequence was presented in the reverse order (i.e., place/spatial training before cued training), 5XFAD mice showed impairments in place/spatial training, but no differences in cued training or in the strategy preference test comparing to control. Analysis of regional Abeta42 deposition in brains of 5XFAD mice showed that the hippocampus, which is involved in the place/spatial learning strategy, had the highest levels of Abeta42 and the dorsal striatum, which is involved in cued learning strategy, showed a small increase in Abeta42 levels. The effect of training protocol order on performance, and regional differences in Abeta42 deposition observed in 5XFAD mice, suggest differential functional recruitment of brain structures related to learning in healthy and AD individuals. |
