| First Author | Nagare R | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 11436 |
| PubMed ID | 32651420 | Mgi Jnum | J:294037 |
| Mgi Id | MGI:6453032 | Doi | 10.1038/s41598-020-68199-5 |
| Citation | Nagare R, et al. (2020) Robust light-dark patterns and reduced amyloid load in an Alzheimer's disease transgenic mouse model. Sci Rep 10(1):11436 |
| abstractText | Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Abeta) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to investigate the effects of altering photophase strength on AD-associated differences in cortical Abeta42 levels, wheel-running activity, and circadian free-running period (tauDD). We found that increasing light levels significantly reduced cortical Abeta42 accumulation and activity levels during the light phase of the light:dark cycle, the latter being consistent with decreased sleep fragmentation and increased sleep duration for mice exposed to the more robust light-dark pattern. No significant changes were observed for tauDD. Our results are consistent with circadian pacemaker period being relatively unaffected by Abeta pathology in AD, and with reductions in cortical Abeta loads in AD through tailored lighting interventions. |
