| First Author | Kantarci A | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 18561 |
| PubMed ID | 33122702 | Mgi Jnum | J:298930 |
| Mgi Id | MGI:6472222 | Doi | 10.1038/s41598-020-75517-4 |
| Citation | Kantarci A, et al. (2020) Microglial response to experimental periodontitis in a murine model of Alzheimer's disease. Sci Rep 10(1):18561 |
| abstractText | Periodontal disease (PD) has been suggested to be a risk factor for Alzheimer's disease (AD). We tested the impact of ligature-induced PD on 5xFAD mice and WT littermates. At baseline, 5xFAD mice presented significant alveolar bone loss compared to WT mice. After the induction of PD, both WT and 5xFAD mice experienced alveolar bone loss. PD increased the level of Iba1-immunostained microglia in WT mice. In 5xFAD mice, PD increased the level of insoluble Abeta42. The increased level in Iba1 immunostaining that parallels the accumulation of Abeta in 5xFAD mice was not affected by PD except for a decrease in the dentate gyrus. Analysis of double-label fluorescent images showed a decline in Iba1 in the proximity of Abeta plaques in 5xFAD mice with PD compared to those without PD suggesting a PD-induced decrease in plaque-associated microglia (PAM). PD reduced IL-6, MCP-1, GM-CSF, and IFN-gamma in brains of WT mice and reduced IL-10 in 5xFAD mice. The data demonstrated that PD increases neuroinflammation in WT mice and disrupts the neuroinflammatory response in 5xFAD mice and suggest that microglia is central to the association between PD and AD. |
