| First Author | Lu Q | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 497 |
| Issue | 4 | Pages | 1031-1037 |
| PubMed ID | 29486157 | Mgi Jnum | J:270373 |
| Mgi Id | MGI:6277713 | Doi | 10.1016/j.bbrc.2018.02.165 |
| Citation | Lu Q, et al. (2018) Abnormalities of the serotonergic system in diacylglycerol kinase delta-deficient mouse brain. Biochem Biophys Res Commun 497(4):1031-1037 |
| abstractText | We previously reported that brain-specific diacylglycerol kinase (DGK) delta-knockout (KO) mice showed obsessive-compulsive disorder (OCD)-like behaviors, which were alleviated by a serotonin (5-HT) transporter (SERT) inhibitor. However, the molecular mechanisms causing the OCD-like abnormal behaviors remain unclear. In the present study, we found that DGKdelta deficiency increased SERT protein levels in the mouse cerebral cortex. Moreover, DGKdelta interacted and co-localized with SERT. Furthermore, DGKdelta-KO decreased tryptophan hydroxylase-2 expression and increased monoamine oxidase-A expression. Indeed, the amount of 5-HT in the cerebral cortex was significantly decreased in DGKdelta-KO mice. These data strongly suggest that OCD-like behaviors in the DGKdelta-KO mice are caused by comprehensive and composite serotonergic hypofunction. |
