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Publication : Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.

First Author  Chang VY Year  2024
Journal  iScience Volume  27
Issue  7 Pages  110306
PubMed ID  39055915 Mgi Jnum  J:352148
Mgi Id  MGI:7704761 Doi  10.1016/j.isci.2024.110306
Citation  Chang VY, et al. (2024) Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells. iScience 27(7):110306
abstractText  Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid skewing, increased multipotent colony formation, and increased HSC repopulation in primary and secondary transplantation assays. Mice transplanted with aged, EGF-treated HSCs displayed increased donor cell engraftment within BM HSCs and systemic administration of EGF to aged mice increased HSC self-renewal capacity in primary and secondary transplantation assays. Expression of a dominant negative EGFR in Scl/Tal1(+) hematopoietic cells caused increased myeloid skewing and depletion of long term-HSCs in 15-month-old mice. EGF treatment decreased DNA damage in aged HSCs and shifted the transcriptome of aged HSCs from genes regulating cell death to genes involved in HSC self-renewal and DNA repair but had no effect on HSC senescence. These data suggest that EGFR signaling regulates the repopulating capacity of aged HSCs.
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