| First Author | Yoshimura R | Year | 2016 |
| Journal | Biosci Biotechnol Biochem | Volume | 80 |
| Issue | 2 | Pages | 288-90 |
| PubMed ID | 26745679 | Mgi Jnum | J:346031 |
| Mgi Id | MGI:6783172 | Doi | 10.1080/09168451.2015.1083397 |
| Citation | Yoshimura R, et al. (2016) Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1alpha knockout mice. Biosci Biotechnol Biochem 80(2):288-90 |
| abstractText | Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1alpha knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1alpha knockout mice. These data suggest that skeletal muscle-PGC-1alpha is important for leucine-mediated mTOR activation and protein biosynthesis. |
