| First Author | Bachmann SB | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 11 | Pages | 3305-3314.e13 |
| PubMed ID | 31189113 | Mgi Jnum | J:288895 |
| Mgi Id | MGI:6431903 | Doi | 10.1016/j.celrep.2019.05.050 |
| Citation | Bachmann SB, et al. (2019) A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions. Cell Rep 27(11):3305-3314.e13 |
| abstractText | Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in vivo. While skin-draining collecting LVs express muscarinic, alpha1- and beta2-adrenergic receptors on lymphatic endothelial cells and smooth muscle cells, intestinal lacteals express only beta-adrenergic receptors and muscarinic receptors on their smooth muscle cells. Quantitative in vivo near-infrared imaging of the exposed flank-collecting LV revealed that muscarinic and alpha1-adrenergic agonists increased LV contractility, whereas activation of beta2-adrenergic receptors inhibited contractility and initiated nitric oxide (NO)-dependent vasodilation. Tumor-draining LVs were expanded and showed a higher innervation density and contractility that was reduced by treatment with atropine, phentolamine, and, most potently, isoproterenol. These findings likely have clinical implications given the impact of lymphatic fluid drainage on intratumoral fluid pressure and thus drug delivery. |
